Paraneoplastic acrokeratosis

This article is about the cutaneous condition Bazex syndrome. For the inherited condition Bazex syndrome, see Bazex–Dupré–Christol syndrome.
Paraneoplastic acrokeratosis
Other names: Acrokeratosis paraneoplastica of Bazex and Acrokeratosis neoplastica)[1]
SpecialtyDermatology

Paraneoplastic acrokeratosis, or Bazex syndrome is a cutaneous condition characterized by psoriasiform changes of hands, feet, ears, and nose, with involvement of the nails and periungual tissues being characteristic and indistinguishable from psoriatic nails. The condition is associated with carcinomas of the upper aerodigestive tract.[2]: 665 

Signs and symptoms

  • Paraneoplastic acrokeratosis
    Paraneoplastic acrokeratosis
  • Paraneoplastic acrokeratosis
    Paraneoplastic acrokeratosis
  • a) Dark red, infiltrative, desquamative plaques on nose/cheeks b) dark red, infiltrative plaques with scales on auricle c) confluent erythema on knees d) infiltrative erythematous plaques with scales ; all fingernails were yellow-brown/thickened e) both plantar pedis were discolored/hyperkeratotic
    a) Dark red, infiltrative, desquamative plaques on nose/cheeks b) dark red, infiltrative plaques with scales on auricle c) confluent erythema on knees d) infiltrative erythematous plaques with scales ; all fingernails were yellow-brown/thickened e) both plantar pedis were discolored/hyperkeratotic
  • a-b) After treatment with gefinitib
    a-b) After treatment with gefinitib

History

This was first reported by the French dermatologist, Andre Bazex (1911–1988), in 1945. Contrary to some publications, he did not die in 1944, as a victim of the Battle for France, but instead, was alive and well and continued his research on skin diseases up until his retirement in 1980.[3]

See also

References

  1. ↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  2. ↑ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
  3. ↑ Eric Ehrsam (February 20, 2008). "Acrokeratosis paraneoplastica in a 45-yr-old man". Archived from the original on September 17, 2019. Retrieved December 7, 2020.
Classification
External resources
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