Humoral immune deficiency

Humoral immune deficiency
B cells and antibody
SpecialtyHematology Edit this on Wikidata
SymptomsSinusitis[1]
CausesAbsent B cells(primary),[2][3] Multiple myeloma(secondary)[4]
Diagnostic methodB cell count, Family medical history[5][6]
TreatmentImmunoglobulin replacement therapy[5]

Humoral immune deficiencies are conditions which cause impairment of humoral immunity, which can lead to immunodeficiency. It can be mediated by insufficient number or function of B cells, the plasma cells they differentiate into, or the antibody secreted by the plasma cells.[7] The most common such immunodeficiency is inherited selective IgA deficiency, occurring between 1 in 100 and 1 in 1000 persons, depending on population. They are associated with increased vulnerability to infection, but can be difficult to detect (or asymptomatic) in the absence of infection.

Signs and symptoms

Signs/symptoms of humoral immune deficiency depend on the cause, but generally include signs of infection such as:[1]

Causes

Cause of this deficiency is divided into primary and secondary:

Hyper-IgM syndromes(immunoglobulin M)
  • Secondary secondary (or acquired) forms of humoral immune deficiency are mainly due to hematopoietic malignancies and infections that disrupt the immune system:[4]

Diagnosis

Human B cell

In terms of diagnosis of humoral immune deficiency depends upon the following:[5][6]

Treatment

Treatment for B cell deficiency (humoral immune deficiency) depends on the cause, however generally the following applies:[5]

See also

References

  1. 1 2 N. Franklin Adkinson Jr.; Bochner, Bruce S.; Burks, Wesley; Busse, William W.; Holgate, Stephen T. (2013-11-01). Middleton's Allergy: Principles and Practice. Elsevier Health Sciences. p. 1134. ISBN 9780323085939.
  2. 1 2 "Pure B-Cell Disorders: Background, Pathophysiology, Epidemiology". 2017-01-06. {{cite journal}}: Cite journal requires |journal= (help)
  3. 1 2 Notarangelo L, Casanova JL, Conley ME, et al. (2006). "Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee Meeting in Budapest, 2005". J. Allergy Clin. Immunol. 117 (4): 883–96. doi:10.1016/j.jaci.2005.12.1347. PMID 16680902.
  4. 1 2 Page 432, Chapter 22, Table 22.1 in: Jones, Jane; Bannister, Barbara A.; Gillespie, Stephen H. (2006). Infection: Microbiology and Management. Wiley-Blackwell. ISBN 978-1-4051-2665-6.
  5. 1 2 3 4 Fried, Ari J.; Bonilla, Francisco A. (2009-07-01). "Pathogenesis, Diagnosis, and Management of Primary Antibody Deficiencies and Infections". Clinical Microbiology Reviews. 22 (3): 396–414. doi:10.1128/CMR.00001-09. ISSN 0893-8512. PMC 2708392. PMID 19597006.
  6. 1 2 Cecil, Russell La Fayette; Goldman, Lee; Schafer, Andrew I. (2012-01-01). Goldman's Cecil Medicine, Expert Consult Premium Edition -- Enhanced Online Features and Print, Single Volume,24: Goldman's Cecil Medicine. Elsevier Health Sciences. p. 1618. ISBN 978-1437716047.
  7. Pieper, Kathrin; Grimbacher, Bodo; Eibel, Hermann (2013-04-01). "B-cell biology and development". Journal of Allergy and Clinical Immunology. 131 (4): 959–971. doi:10.1016/j.jaci.2013.01.046. ISSN 0091-6749. PMID 23465663.

Further reading

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