Clidinium bromide

Clidinium bromide
Names
IUPAC name
  • 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-1-azabicyclo[2.2.2]octan-1-ium bromide
Clinical data
Pregnancy
category
  • US: D (Evidence of risk)
    Routes of
    use
    By mouth
    External links
    AHFS/Drugs.comMonograph
    US NLMClidinium bromide
    MedlinePlusa601036
    Legal
    Legal status
    Pharmacokinetics
    BioavailabilityLow
    ExcretionKidney and biliary
    Chemical and physical data
    FormulaC22H26NO3+
    Molar mass352.454 g·mol−1
    3D model (JSmol)
    SMILES
    • O=C(OC2C1CC[N+](CC1)(C)C2)C(O)(c3ccccc3)c4ccccc4
    InChI
    • InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1 checkY
    • Key:HOOSGZJRQIVJSZ-UHFFFAOYSA-N checkY

    Clidinium bromide is an anticholinergic (specifically a muscarinic antagonist) medication.[1] It may help symptoms of cramping and abdominal pain by slowing the intestines.

    In the United States it is only commercially available in combination with chlordiazepoxide (a benzodiazepine) as chlordiazepoxide/clidinium.[2]

    Mechanism of action

    Clidinium inhibits muscarinic acetylcholine receptors on smooth muscles, secretory glands, and in the central nervous system to relax smooth muscle and decrease biliary tract secretions.[3]

    References

    1. "Clidinium bromide". Drugs.com. Archived from the original on August 28, 2018. Retrieved August 24, 2013.
    2. "Clidinium Monograph for Professionals". Drugs.com. Archived from the original on 28 August 2018. Retrieved 5 January 2022.
    3. 2014 Nurses Drug Handbook (13th ed.). Burlington, MA: Jones & Bartlett Learning. 2014. pp. 245-6. ISBN 978-1-284-03115-7.
    Identifiers:
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