Doravirine

Not to be confused with drotaverine.
Doravirine
Names
Trade namesPifeltro
Other namesMK-1439
IUPAC name
  • 3-Chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydro-3-pyridinyl}oxy)benzonitrile
Clinical data
Drug classNon-nucleoside reverse transcriptase inhibitor (NNRTI)[1]
Main usesHIV/AIDS[1]
Side effectsNausea, dizziness, headache, tiredness, diarrhea, abnormal dreams[1]
Routes of
use		By mouth[1]
Typical dose100 mg OD[2]
External links
AHFS/Drugs.comMonograph
US NLMDoravirine
MedlinePlusa618048
Legal
License data
Legal status
Chemical and physical data
FormulaC17H11ClF3N5O3
Molar mass425.75 g·mol−1
3D model (JSmol)
SMILES
  • Cn1c(n[nH]c1=O)Cn2ccc(c(c2=O)Oc3cc(cc(c3)Cl)C#N)C(F)(F)F
InChI
  • InChI=1S/C17H11ClF3N5O3/c1-25-13(23-24-16(25)28)8-26-3-2-12(17(19,20)21)14(15(26)27)29-11-5-9(7-22)4-10(18)6-11/h2-6H,8H2,1H3,(H,24,28)
  • Key:ZIAOVIPSKUPPQW-UHFFFAOYSA-N

Doravirine, sold under the brand name Pifeltro, is a medication used to treat HIV/AIDS.[1] It is taken together with other HIV medicines.[1] It is taken by mouth, generally once per day.[1]

Common side effects include nausea, dizziness, headache, tiredness, diarrhea, and abnormal dreams.[1] Other side effects may include immune reconstitution syndrome.[1] Safety in pregnancy is unclear.[4] It is a non-nucleoside reverse transcriptase inhibitor (NNRTI).[1]

Doravirine was approved for medical use in the United States and Europe in 2018.[2] In the United Kingdom a month of medication costs the NHS about £470 as of 2021.[5] This amount in the United States is about 1,500 USD.[6] It is also available as the combination doravirine/lamivudine/tenofovir.[5]

Medical uses

Dosage

It is generally taken at a dose of 100 mg per day.[2]

References

  1. 1 2 3 4 5 6 7 8 9 10 11 "Pifeltro- doravirine tablet, film coated". DailyMed. 10 October 2019. Archived from the original on 28 October 2020. Retrieved 22 September 2020.
  2. 1 2 3 4 "Pifeltro EPAR". European Medicines Agency (EMA). Archived from the original on 28 October 2020. Retrieved 1 October 2020.
  3. ↑ "Pifeltro 100 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 26 September 2020. Retrieved 1 October 2020.
  4. ↑ "Doravirine (Pifeltro) Use During Pregnancy". Drugs.com. Archived from the original on 3 December 2020. Retrieved 27 December 2021.
  5. 1 2 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 683. ISBN 978-0857114105.
  6. ↑ "Pifeltro Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 27 December 2021.
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