HBQ1

HBQ1
Identifiers
AliasesHBQ1, HBQ, hemoglobin subunit theta 1
External IDsOMIM: 142240 MGI: 3613460 HomoloGene: 3895 GeneCards: HBQ1
Orthologs
SpeciesHumanMouse
Entrez

3049

544763

Ensembl

ENSG00000086506

ENSMUSG00000073063

UniProt

P09105

Q3U0A6

RefSeq (mRNA)

NM_005331

NM_001033981

RefSeq (protein)

NP_005322

NP_001029153

Location (UCSC)Chr 16: 0.18 – 0.18 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Hemoglobin subunit theta-1 is a protein that in humans is encoded by the HBQ1 gene.[4][5]

Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000086506 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
  5. 1 2 "Entrez Gene: HBQ1 hemoglobin, theta 1".

Further reading


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