Ozenoxacin

Ozenoxacin
Names
Pronunciationoz en ox' a sin
Trade namesOzanex; Xepi
IUPAC name
  • 1-Cyclopropyl-8-methyl-7-[5-methyl-6-(methylamino)-3-pyridinyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
Clinical data
Drug classAntibiotic (quinolone)[1]
Main usesImpetigo[1]
Side effectsUncommon[2]
Pregnancy
category
  • US: N (Not classified yet)
    Routes of
    use    		Topical
    External links
    AHFS/Drugs.comMonograph
    US NLMOzenoxacin
    MedlinePlusa618010
    Legal
    License data
    Legal status
    Chemical and physical data
    FormulaC21H21N3O3
    Molar mass363.417 g·mol−1
    3D model (JSmol)
    SMILES
    • O=C\3c1c(c(c(cc1)c2cc(c(nc2)NC)C)C)N(/C=C/3C(=O)O)C4CC4
    InChI
    • InChI=1S/C21H21N3O3/c1-11-8-13(9-23-20(11)22-3)15-6-7-16-18(12(15)2)24(14-4-5-14)10-17(19(16)25)21(26)27/h6-10,14H,4-5H2,1-3H3,(H,22,23)(H,26,27)
    • Key:XPIJWUTXQAGSLK-UHFFFAOYSA-N

    Ozenoxacin, sold under the brand names Ozanex and Xepi, is an antibiotic used to treat impetigo.[1] This includes impetigo due to methicillin-resistant S. aureus (MRSA).[2] It is applied to the skin as a cream.[2]

    As little is absorbed through the skin; side effects are uncommon.[2] Side effects may include seborrheic dermatitis.[4] It is not expected to be harmful in pregnancy or breastfeeding.[1] It is a quinolone and works by blocking DNA gyrase A and topoisomerase IV.[1]

    Ozenoxacin was approved for medical use in the United States and Canada in 2017.[1][5] In the United States a 30 gram tube of 1% cream costs about 340 USD as of 2021.[6] This amount in Canada costs about 53 CAD.[7]

    Medical use

    Ozenoxacin is used to treat impetigo caused by S. aureus and S. pyogenes .[2] It may also be used to get rid of methicillin-resistant S. aureus (MRSA).[2]

    Dosage

    It is used as a 1% cream applied twice daily for 5 days in those over the age of 2 months.[2]

    References

    1. 1 2 3 4 5 6 "DailyMed - XEPI- ozenoxacin cream". dailymed.nlm.nih.gov. Archived from the original on 11 November 2021. Retrieved 10 November 2021.
    2. 1 2 3 4 5 6 7 Robertson, Dirk B.; Maibach, Howard I. (2020). "61. Dermatologic pharmacology". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (15th ed.). New York: McGraw-Hill. p. 1112. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-11-07.
    3. ↑ "Xepi- ozenoxacin cream". DailyMed. 30 January 2020. Archived from the original on 17 October 2020. Retrieved 13 October 2020.
    4. ↑ "Ozenoxacin Monograph for Professionals". Drugs.com. Archived from the original on 15 October 2020. Retrieved 10 November 2021.
    5. ↑ Canada, Health (30 June 2017). "Notice: Prescription Drug List (PDL): Multiple Additions [2017-06-23]". www.canada.ca. Archived from the original on 8 July 2021. Retrieved 10 November 2021.
    6. ↑ "Xepi Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 10 November 2021.
    7. ↑ "Pharmacoeconomic Review Report" (PDF). CADTH. Archived (PDF) from the original on 19 October 2019. Retrieved 10 November 2021.
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