7-Hydroxyamoxapine

7-Hydroxyamoxapine
Names
Preferred IUPAC name
2-Chloro-11-(piperazin-1-yl)dibenzo [b,f][1,4]oxazepin-7-ol
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
PubChem CID
UNII
InChI
  • InChI=1S/C17H16ClN3O2/c18-11-1-4-15-13(9-11)17(21-7-5-19-6-8-21)20-14-3-2-12(22)10-16(14)23-15/h1-4,9-10,19,22H,5-8H2 checkY
    Key: MEUGUMOVYNSGEW-UHFFFAOYSA-N checkY
  • InChI=1/C17H16ClN3O2/c18-11-1-4-15-13(9-11)17(21-7-5-19-6-8-21)20-14-3-2-12(22)10-16(14)23-15/h1-4,9-10,19,22H,5-8H2
    Key: MEUGUMOVYNSGEW-UHFFFAOYAF
SMILES
  • Clc2ccc1Oc4c(/N=C(\c1c2)N3CCNCC3)ccc(O)c4
Properties
Chemical formula
 C17H16ClN3O2
Molar mass 329.78 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

7-Hydroxyamoxapine is an active metabolite of amoxapine (Asendin). It contributes to amoxapine's pharmacology.[1][2]

See also

References

  1. ↑ Jue, SG; Dawson, GW; Brogden, RN (July 1982). "Amoxapine: A Review of its Pharmacology and Efficacy in Depressed States". Drugs. 24 (1): 1–23. doi:10.2165/00003495-198224010-00001. PMID 7049659.
  2. ↑ Calvo, B; García, MJ; Pedraz, JL; Mariño, EL; Domínguez-Gil, A (April 1985). "Pharmacokinetics of amoxapine and its active metabolites". International Journal of Clinical Pharmacology, Therapy, and Toxicology. 23 (4): 180–185. PMID 3997304.


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